Press Release

Spirit Spine to Present at International Congress of Chinese Orthopaedic Association

Pasadena, CA … July 22, 2013

Spirit Spine Holdings Corp., Inc., a spinal device company developing innovative solutions for the treatment of the spinal interventional and minimally invasive procedures, today announced it will be participating in the 8th International Congress of Chinese Orthopaedic Association, being held on Nov 7-10, 2013 in China National Convention Center, Beijin, China.

About Spirit Spine

Headquartered in Pasadena, USA, Spirit Spine Holdings Corporation, Inc. (Spirit Spine) is a medical device company dedicated solely to provide the most advanced technologies and options in treating the Vertebral Compression Fractures (V.C.F.) caused by Osteoporosis.

Our mission is “Simplicity, Stability, and Safety” for Spine Surgeries. In addition to our existing product lines, we are currently pursuing a strategy to globally commercialize our latest development, KyVex™, The Advanced Vesselplasty System, along with our Osteo-G® Osteo-Inductive Bone Cement, to efficiently treat patients who suffer from back pains created from spinal compression fractures.

www.SpiritSpine.com

Spirit Spine Announces CFDA Clearance for the Vessel-X System

Pasadena, CA … November 26, 2013

Spirit Spine Holdings Corp., Inc., a spinal device company developing innovative solutions for the treatment of the spinal interventional and minimally invasive procedures, today announced it has received the Class III clearance from the China Food and Drug Administration (CFDA) to market the Vessel-X Systems, also known as the Vesselplasty in China. This new addition to the company’s growing minimally invasive procedures for Vertebral Compression Fractures (VCFs) portfolio is designed to replace collapsed, damaged, or unstable vertebral bodies due to trauma or osteoporosis and provide rebalancing spinal column support.

Vessel-X, manufactured from controlled pore size fabric according to the particle size of different types of the bone cements allows the injected bone cement stays within the Vessel-X container without leaking out while the filling. When the Vessel-X reaches it's maximum volume, the small amount of the bone cement begins to wuss out around the container consistently under surgeon's control to create the perfect interdigitation in almost every Vesselplasty cases.

“CFDA clearance for Vessel-X is an important expansion and milestone of offering the complete product line of vertebral compression fractures in China especially in the areas of trauma and osteoporosis spinal surgeries,” stated Daniel Lin, Spirit Spine's CEO. “We have waited this day for many years, and as the first addition to Spirit Spine's portfolio in 2014, we’re proud to offer surgeons and patients in China a new product line that continue to highlight our commitment to treating the VCF's.”

www.SpiritSpine.com

Spirit Spine Promotes Jack Ting as General Manager

Pasadena, CA … January 31, 2014

Spirit Spine Holdings Corp., Inc., a spinal device company developing innovative solutions for the treatment of the spinal interventional and minimally invasive procedures, today announced the appointment of Jack Ting as General Manager, an important milestone in the company’s strategic plan to become a global leader in the interventional spinal market.

Jack joined the company with decent experience in marketing and sales, including his successful business developments with The Home Depot and Costco Wholesale. With his mechanical engineering and industrial engineering background, Jack has also helped the company to strengthen its supply chain as well as its product liability.

“We believe Jack has proved his value to the organization, and we are looking forward to his leadership with more of his contribution.” Said Daniel Lin, the CEO and the founder of Spirit Spine.

“It’s an honor to be recognized by the board members.” said Ting. “We are ready to explore more markets and accelerate our market expansion. We have excellent products and it is time to have more patients to have benefits from them. It is our goal to grow and have a big boom in China, France, Germany, and UK in the next 3 years”

Mr. Ting holds a Master of Science in Industrial Engineering from the University of Texas at Arlington.

www.SpiritSpine.com

Spirit Spine Kicks off Vessel-X® Sales Campaign in China

Pasadena, CA … February 24, 2014

As the first shipment of Vessel-X® Bone Filling Container System hit the receiving dock of the warehouse in Wai Gao Qiao Free Trade Zone in Shanghai, Spirit Spine Holdings Corp., Inc. officially kicks off its sales campaign of this product line in China. Following the receipt of the Class III clearance from the China Food and Drug Administration (CFDA), Spirit Spine is putting its efforts to introduce this innovative minimally invasive procedures for Vertebral Compression Fractures (VCFs) to China market.

“The surgeons and patients have been longing for a better solution for VCFs treatment.” said Daniel Lin, Spirit Spine's CEO. “And now, we are answering their requests by bringing them Vessel-X® as we’ve promised years ago.”

“We have been working with the distributors in China to pre-advertise Vessel-X®.” stated Jack Ting who has just appointed as G.M. of the company. “Though there will be a series of jobs to be done before Vessel-X® presents itself in the O.R.s, such as pricing, insurance coding, and tenders, the sales network has been ready for it.”

Vessel-X®, manufactured from controlled pore size fabric according to the particle size of different types of the bone cements, allows the injected bone cement stays within the Vessel-X® container without leaking out while the filling. When the Vessel-X® container reaches it's maximum volume, the small amount of the bone cement begins to wuss out around the container consistently under surgeon's control to create the perfect inter-digitation in almost every Vesselplasty cases.

www.SpiritSpine.com

Spirit Spine Moves Global HQ to Taipei, Taiwan

Pasadena, CA … May 13, 2014

Spirit Spine Holdings Corp., Inc., a spinal device company developing innovative solutions for the treatment of the spinal interventional and minimally invasive procedures, today announced the company will officially move its global HQ to Taipei, Taiwan, starting June 01, 2014.

"This is to better serve our fast growing Asia market and future corporate strategic planning," said Daniel Lin, Spirit Spine CEO. "This relocation will also improve our business operations and logistics as we utilize the strength of our Taipei manufacture's recent expansion."

“Considering our main markets – Europe, Asia, especially China,” said Jack Ting, Spirit Spine G.M. “We need a fast-responded mechanism to serve our customers.”

Spirit Spine had received the Class III clearance from the China Food and Drug Administration (CFDA) to market the Vessel-X Systems in November 2013, and has been drawing more attentions from other Asian countries, such as India, Thailand, and Korea.

Spirit Spine will keep its current US office for contact its vendors.

www.SpiritSpine.com

Spirit Spine Appoints Dr. Chong-Chou Lee as CEO

Taipei, Taiwan ….. Dec. 1, 2014

Spirit Spine Holdings Corp., Inc., a spinal device company developing innovative solutions for the treatment of the spinal interventional and minimally invasive procedures, today announced the appointment of Dr. Chong-Chou Lee as Chief Executive Officer starting from Jan 1, 2015, an important milestone in the company’s strategic plan to become a global leader in the interventional spinal market.

Dr. Chong-Chou Lee PhD is best known as the helmsman behind Taiwan's national biotechnology industry strategy while he was serving as the Director in the Office of Science & Technology Advisory Group in Executive Yuan (Cabinet).

Prior joining Spirit Spine, Dr. Lee was the president of Medigen Vaccinology Corp. where he oversees all aspects of vaccine development, including strategic direction, clinical trials and regulatory path, collaborations and strategic alliances, and construction of cell-based vaccine facility. Dr. Lee has over 20 years of experiences in the biotechnology sector specialized in cellular and molecular technologies.

Dr. Lee has a Ph.D in Cellular and Structural Biology from University of Texas Health Science Center at San Antonio, and the postdoctoral training at National Institutes of Health in Bethesda, Maryland.

www.SpiritSpine.com

Spirit Spine to Present at EuroSpine 2015

Taipei, Taiwan ….. Jan 12, 2015

Spirit Spine Holdings Corp., Inc., a spinal device company developing innovative solutions for the treatment of the spinal interventional and minimally invasive procedures, today announced it will be participating in the EuroSpine 2015, being held on September 2-4, 2015 in Bella Center Copenhagen, Denmark, at their exhibit Hall C2, Booth No.83.

About Spirit Spine

Headquartered in Taipei, Taiwan, Spirit Spine Holdings Corporation, Inc. (Spirit Spine) is a medical device company dedicated solely to provide the most advanced technologies and options in treating the Vertebral Compression Fractures (V.C.F.) caused by Osteoporosis.

Our mission is “Simplicity, Stability, and Safety” for Spine Surgeries. In addition to our existing product lines, we are currently pursuing a strategy to globally commercialize our latest development, KyVex™, The Advanced Vesselplasty System, along with our Osteo-G® Osteo-Inductive Bone Cement, to efficiently treat patients who suffer from back pains created from spinal compression fractures.

www.SpiritSpine.com

Spirit Spine to Publish Vessel-X® at Spinal News International

Taipei, Taiwan ….. Feb 16, 2015

Spirit Spine Holdings Corp., Inc., a spinal device company developing innovative solutions for the treatment of the spinal interventional and minimally invasive procedures, today proudly announced an interview about Vessel-X® from Dr. Bambang Darwono (Former Colonel of Indonesian Army and world-renown surgeon) and Spine News’ Editor Mr. David Brennan will be published at Spinal News International, July’s edition (Issue No. 36).

About Vessel-X® Bone Filling Container System

An approved novel vertebral osteoplasty technique, designed to implant a Vessel-X®, a non-stretchable fabric in the trabecular bone to form a treating step by filling the bone filler materials. Its purpose is not only to restore the height of a vertebral body but also solve the common/fatal problem of cement leakage in the vertebral body.

www.SpiritSpine.com